The Vaccine Competition Will Be Ruthless

DISPATCHES FROM MOON OF ALABAMA, BY "B"
This article is part of an ongoing series of dispatches from Moon of Alabama

Debs is dead writes:

[T]he pushback against AstraZeneca including the latest link which is all speculation mixed with the same trash talk wall st analysts have been making, is a blatant move by big pharma to edge AstraZeneca out of the market.

There is more testing to be done on the AstraZeneca vaccine. Yes the discovery of a half dose followed by a full dose seeming to be more efficacious was the result of a distribution accident in one particular cohort comprised of Englanders under 55, AstraZeneca have realised that and have undertaken to extend the 50/100 trial across all age groups and ethnicities in the next testing round.

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Also despite the fact that the big pharma mRNA vaccines have published no peer reviewed results, AstraZeneca report that they have sent a peer reviewed study of their complete test results thus far, to the Lancet and they expect these to be published in the next edition of the journal - likely within the next few days.

However many people whine, bitch about all others, then salute the results of Russian & Chinese vaccines the simple fact is a great many communities will be denied access to Russian or Chinese vaccines - that is a reality. Some of these states are in no shape to subscribe to the mRNA vaccines without 'aid' (i.e. ripoff loans) because their health budgets are still having to cover the double Tamiflu scam (they had to sign contracts to replace 'expired' Tamiflu stocks used or not after 3 years) and the more recent Remdesivir scam, all perpetrated by Gilead.

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In the real world that means if the AstraZeneca vaccine is more than 60% efficacious (which is better than any flu vaccine - 95% is new big pharma BS IMO) and has no major side effects (one case of MS tells us nothing for the reason I outlined above), then it will be that or nothing for a sizeable slab of the world's population.

If everyone falls for big pharma's transparent attempt to stop this possible vaccine in its tracks, prior to testing completion, then that will mean no vaccine for billions of our fellow humans, so rather than joining in the big pharma sabotage, it makes better sense to consider that vaccine more objectively than de Noli, that Harvard minion of corporations seems to do.

Of course for some theoretical Marxist whose crazed ramblings remind me of the immature garbage one could hear around any Lisbon praça, circa 1975, that will mean little. As the humans of Mozambique, Angola and in particular since I lost friends there , Timor Leste, discovered to their cost.

I agree with the above.

Sure, AstraZeneca has not communicated well. They should have published their trial protocols. They should have been more explicit about their dosing 'mistake'. But the results of their trials are encouraging and the explanation for the higher efficacy with a lower first dose, see below, makes sense.

The AstraZeneca vaccine uses an adenovirus as 'vector' to deliver a DNA sequence that human cells then use to create one specific (but harmless) SARS-CoV-2 protein. The immune system will then learn to attack that protein. Afterwards it should be able to protect against SARS-CoV-2 infections.

There are 57 different adenovirusus that usually occur in humans. Most of us have been infected by some of them, likely in our youth, and have developed some grade of immunity against them. An adenovirus that has been modified to become a vaccine against SARS-CoV-2 may therefore be attacked by our immune system before it can achieve its purpose. We may have some 'vector immunity' against some of the adenovirus based vaccines.

To avoid that an already existing immunity against human adenoviruses prevents the desired inoculation AstraZeneca is using a chimpanzee-originated version of an adenovirus as a vector. The Russian Sputnik V vaccine, hyped by Prof. de Noli on RT,  uses two doses with different human adenoviruses (Ad-26, Ad-5) as vectors to increase the chance of inoculation. Other vaccine developers, CanSino Biologics and Johnson & Johnson, are also using adenovirus vectors. Sinopharm's vaccine uses an inactivated SARS-CoV-2 virus.

AstraZeneca found by chance that its vaccine works best when the first dose is smaller than the second one. Vector immunity can explain why this is the case. A first high dose will create some immunity against the SARS-CoV-2 virus but also some immunity against the vector virus, the chimpanzee-originated adenovirus. When a first high dose has trained the immune system to fight the vector virus the second 'booster' vaccine dose using the same vector will become inefficient. A lower first dose can make sure that the second higher dose is not prematurely defeated by vector immunity but can still do its work.

The AstraZeneka vaccine was developed by Oxford University. It will be a no-profit vaccine as its development was financed by public money. The cost per dose will be below $3-4.

Both of the mRNA vaccines developed by Moderna and Pfizer are for-profit vaccines. They seem to be quite good (and no, they do not modify your DNA) but they will cost between $25 and $35 per shot. They also require an elaborate and expensive distribution chain as they can only be stored at very low temperatures. The adenovirus based vaccines can be stored in a normal refrigerator.

The mRNA vaccines hyped in the U.S. media are simply too expensive to be used around the world. If we want to limit the global effects of the SARS-CoV-2 pandemic we will have to use the cheaper vector based vaccines.

That the AstraZeneca vaccine was immediately attacked in U.S. media by an unqualified writer quoting an investment bank and the U.S. pharma promoting (Remdesivir!) Antony Fauci is quite suspicious. Pfizer and Moderna expect to make billions of dollars with their vaccines. They will use all possible ways and means to defeat any potential competition.

None of the results of the ongoing trials under discussion have so far been published in a peer reviewed format. We will have to wait until the end of the trials and the reviewed publication of the results to judge about their real efficacy and potential side effects.

Until then we should be careful not to fall for misinformation from big pharma interests. Nor should we fall for the nonsense from the anti-vaccine crowd.

So far all of the vaccines under discussion seem to be safe and efficient enough to defeat the pandemic. I for one see no reason to reject any of them.

Posted by b on November 27, 2020 at 11:18 UTC | Permalink

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